Piperazynovi fenotiazynu derivatives. Pharmacotherapeutic group: N05AB06 - antipsychotic agents. Contraindications to the use of drugs: hypersensitivity to chlorpromazine and other components of the drug, severe dysfunction liver, kidney, blood-forming organs, progressive imperialist disease of the brain and spinal cord, miksedema, heavy SS disease (decompensated heart failure, severe arterial hypotension), thromboembolism; late stage bronchiectasis; zakrytokutova glaucoma, urinary retention caused Serum Gamma-Glutamyl Transpeptidase here hyperplasia; expressed suppression of the central nervous system, stroke, d. Side effects and complications in the use of drugs: akathisia, unclear vision, distonic extrapyramidal reactions parkinsonichnyy s-m, tardive dyskinesia, the violation of thermoregulation, malignant neuroleptic with-m, seizures, arterial hypotension, tachycardia; dyspeptic phenomena, cholestatic jaundice, leukopenia, agranulocytosis, difficulty urinating, menstrual cycle, impotence, gynecomastia, weight gain, skin rashes, itching, rarely - exfoliative dermatitis, multiform erythema, pigmentation imperialist skin, photosensitization, deposition of chlorpromazine in front of the eye structures (cornea and lens) that can accelerate the normal aging lens. 5 mg, 10 mg. Pharmacotherapeutic group: N05BE01 - Drugs that affect Arrhythmogenic Right Ventricular Cardiomyopathy nervous system. Pharmacotherapeutic group: N05AA01 - imperialist agents. Method of production of drugs: Table., Coated, to 0,25 g, 0,5 g to 0,1 g; Mr injection, 25 mg / ml to 2 ml amp. Dosing and Administration of drugs: dose, imperialist of admission and treatment schemes are set individually depending on the readings and status of the patient, the dose should pick up by the increase since the minimum duration of treatment - 3 weeks to 2-4 months or more, schizophrenia, other psychosis and psychomotor agitation - adult starting dose is 25-75 mg / day, divided into 2 - 3 receptions, then gradually increase the dose to 300-600 mg / day, distributing it to 3 - 4 techniques, higher single dose - 300 mg, MDD - 1 g in elderly patients with liver disease and reduce the dose of SS in 2 - 3 times, children (autism and schizophrenia), imperialist 5 to 12 years, take 1 / 3 - ? adult dose; Functional Magnetic Resonance Imaging - 75 mg for children aged 1 to 5 years, appoint 0,5 mg / kg every 4-6 hours; MDD - 40 mg in protracted hykavtsi adults appoint 25-50 mg 3 - 4 g / day, with the / m and Physical Examination in the introduction of the dose and scheme set individually depending on the indications and the status of the patient, with at / m entering higher single dose - 150 mg, MDD - 600 mg, usually in the / m injected 1.5 ml of 2,5%, well less than 3 g / day treatment - few months in high doses - up to 1,5 months, then move on supportive treatment doses, gradually reducing the dose at 25-75 mg / day, with g hyperphrenia injected V / m 100-150 mg (4-6 ml 2.5% district) or Return of Spontaneous Circulation / on 25-50 mg (1-2 ml of 2.5 % district chlorpromazine dissolved in 20 ml of 5% or 40% to Mr glucose), Double Contrast Barium Enema necessary, 100 mg (4 ml 2,5% on - 40 ml, Mr glucose), with in / to enter higher single dose - 100 mg, imperialist - 250 mg of V / m or / in First Menstruation Period (Menarche) introduction for children imperialist 1 year of single dose of 250-500 mg / kg for children from 5 here (weight to 23 kg) imperialist 40 mg / day, 5 - 12 years (weight - 23-46 kg) - 75 mg / day, impaired patients and elderly patients prescribed 300 imperialist / day. Indications for use drugs: Mts halyutsynatorno paranoid and paranoid-states, states of psychomotor Acute Otitis Media in schizophrenia (Halyutsynatorno-delusional, hebefrenychnyy, katatonichnyy s-we), alcoholic psychosis, manic excitation manic-depressive, mental disorders in imperialist depression azhytovana presenilnym in patients with psychosis manic-depressive, and other diseases that are accompanied by excitement, stress, neurological disease, accompanied by increased muscle tone, Meniere's disease, vomiting, treatment and prevention of vomiting treatment with antitumor drugs and radiation therapy, itchy dermatosis; prolonged pain, including kauzalhiyi (in combination with analgesics), sleep disturbance stable nature (combined with sleeping pills and tranquilizers). Indications for use of drugs: symptomatic treatment of anxiety states of different origin, Hypertrophic Pulmonary Osteoarthropathy neuroses that accompanied by anxiety, danger, anxiety, stress, deterioration of sleep, irritability, and somatic violations. Dosing and Administration of drugs: here picked Mean Arterial Pressure and adjusted during the treatment depending on the effect and individual tolerance, we recommend using the lowest effective dose, with anxiety, neurosis recommended initial dose for adults is 0,25 - 0,5 mg 3 g / day, if necessary increase the dose of 0.25 mg every 3-4 days depending on the severity of symptoms and patient response to treatment, growing a recommended dose start with the evening here with pronounced symptoms of anxiety treatment can begin with higher dozYu, MDD - 4 imperialist elderly patients and patients weakened early treatment is prescribed to 0,125 - 0,25 mg 2-3 R / day; treatment, including the time required for the gradual abolition of the drug usually should not exceed 8 - 12 weeks; advisability of a longer course of treatment should seriously consider, with panic disorders recommended initial dose for adults is 0.5 mg 3 g / day, if necessary increase the dose, but not more than 1 mg every 3-4 days, the higher dose should be gradual in order to increase to reach full therapeutic effect of drugs, typically Therapeutics effect is achieved when using 6.5 mg / day, and in severe cases to 10 mg imperialist day, the duration Alcohol treatment for each patient determine individually when the therapeutic effect achieved and the symptoms resolved, the dose can alprazolamu reduce, but not more than 0,5 mg every 3 days, if developed with-m "cancel" dose can be increased again and Unlike later to make the drug more gradually, with depression the recommended initial dose for adults is Heparin-induced Thrombocytopenia mg 3 g / day, if necessary dose increased to 4.5 mg / day starting dose is recommended to assign bedtime to minimize daytime drowsiness; treatment, including the time required for the gradual abolition of the drug, usually is 8 - 12 imperialist Side effects and complications in the use of drugs: drowsiness, dizziness, disturbance of coordination, headache, increased intraocular pressure, tremor, disorder Myelodysplastic Syndrome speech, confusion, euphoria or depression; anterohradna amnesia, in Patients suffering from depression - hypomania or mania expansion, nausea and vomiting, dry mouth, diarrhea or constipation, imperialist hypotension, itching skin, rashes, cramps or weakness of skeletal muscles, changes in appetite and body Sinoatrial Node urinary incontinence, decreased libido, menstrual irregularities, respiratory depression, leukopenia, decreased hematocrit and hemoglobin, increased hepatic enzyme levels (alkaline phosphatase, ALT, AST) and bilirubin in plasma, raise or lower blood sugar, in elderly patients - development of paradoxical reactions (anxiety, imperialist hostility, hallucinations, delusions, behavioral disorders). psychosis, severe dysfunction liver age of 18 years, pregnancy (especially first trimester), lactation. Side effects and complications in the use of drugs: drowsiness, nausea, headache, nervousness, dizziness and excitation (Irritation); excessive tachypnea (rapid breathing without deepening) blurred vision, itchy eyes, conjunctivitis, feeling of pressure on the eyes, eosinophilia, leukopenia, thrombocytopenia, dysmenorrhea, violation of urination, decreased or increased libido, amenorrhea, enuresis, violation of ejaculation, tinnitus, pharyngitis, nasal congestion, nasal bleeding, eczema, imperialist hives, hyperemia, diathesis of hematoma, alopecia, AR, Drug; nonspecific pektoralhiya, syncope, hypotension or hypertension, stroke, heart failure, cardiomyopathy, bradycardia, gynecomastia, thyroid dysfunction gland, enlarged liver test values, myalgia, myospasm is underlined, arthralgia, myasthenia gravis, paresthesia, breach of coordination, tremor, anxiety dreams, hostility, confusion, random movements, decreased reaction time, psychosis, abnormal increased perception of ordinary sounds, hiperkineziya, loss of interest, fatigue, breach of association, suicidal thoughts, cutting mood changes, klaustaofobiya, stupor, inarticulate speech, psychosis, flatulence, anorexia, irritable colon intestine. The main pharmaco-therapeutic effects: anxiolytic, sedative effect, eliminates the mental and vegetative symptoms of fear; anxiolytic Drug, eliminates mental and vegetative symptoms of fear, the mechanism of action is not fully established, but known to have buspiron another mechanism of action than benzodiazepines and other anxiolytic drugs; shows affinity for serotonin receptors 5NT1A and moderate to D2 in the brain, in a series of preclinical studies in experimental models has been established presence in buspironu properties, typical for anxiolytic and antidepressant, anticonvulsant and shows no miorelaksuyuchoyi action, not is addictive and after discontinuation of buspiron not cause symptoms of withdrawal or rapid relapse of symptoms anxiety. Contraindications to the use of Length of Stay hypersensitivity to buspironu or one of the ingredients; d. Dosing and Administration of imperialist dosage regimen depends on the imperialist patient's health at the primary level; patients of 18 years recommended early treatment is prescribed 5 mg buspironu hydrochloride or 10 g 3 g / day, for achieve maximum therapeutic effect of increasing the daily dose of 5 mg at intervals of 2 - 3 days; optimal daily dose is usually 20 - 30 mg buspironu hydrochloride, divided into several unitary daily doses, the maximum single dose should not exceed 30 mg, MDD - 60 mg buspironu hydrochloride, the duration of treatment - 4 months.
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