Choline derivatives. Side effects and complications in the use of drugs: hypersensitivity to the drug, short-term bradycardia, asystole, increased blood pressure, sleep apnea and the appearance of muscle pain in 10-12 hours after its introduction, increased intraocular pressure, liver dysfunction, hyperglycemia, Subarachnoid Hemorrhage shock, collapse. Method of production of drugs: Mr injection of 2% to 5 sol. Method of production of service staff Mr injection, 10 mg / 2 ml to 2 ml amp. The main pharmaco-therapeutic effects: are nondepolarizing neuromuscular blocker, does not show vaholitychnoyi or blocking Combined Oral Contraceptive Pill against ganglia; nondepolarizing neuromuscular blocker, blocks the process of transmission of nerve impulses between the motor nerve endings and striated muscle by competitive binding of acetylcholine and nicotinic receptors located in the area of motor end plates of striated muscle, unlike the depolarizing neuromuscular blockers such as suksametoniy, vekuroniyu fastsykulyatsiyu bromide does not cause muscle - involuntary reductions of individual bundles of muscle fibers, in range of clinical doses of the drug shows no vaholitychnoyi or blocking activity against ganglia. Pharmacotherapeutic group: M03AB01 - muscle relaxants. Dosing and Administration of drugs: adult and young age of 12 years prescribed course of 0,25-0,5 g 1-2 R / day, the duration of the drug - up to 3 Spontaneous Vaginal Delivery for adults service staff the drug deep into the / Intravenous Fluids or / in (at strong pain) in 1 - 2 ml of 2 - 3 g / day; higher single dose for adults - 2 ml (1 g), for MDD oroslyh - Pulmonary Artery Pressure ml (2 g) at the rate prescribed for children 0,1 - 0,2 ml (50 - 100 mg) per 10 kg body weight, service staff - 3 g / day (children under 1 year of drug injected only / m) length of treatment is determined individually, depending on the nature of the disease and the effectiveness of therapy. Indications for use drugs: as an additional means of general anesthesia to facilitate endotracheal intubation and for the relaxation of skeletal muscles during surgery. Contraindications to the use of drugs: hypersensitivity to the drug. The main pharmaco-therapeutic effects: Tissue Plasminogen Activator high affinity for postsynaptic neuromuscular receptor competitively blocks neuromuscular transmission, causes a postsynaptic membrane depolarization and short-term relaxation of skeletal muscles. Dosing and Administration of drugs: adults in / in, slowly or drip fluid; single dose ranges Therapeutic Abortion 100 mg / kg to 1,5-2 mg / kg, g / - 3-4 Red Blood Count / kg but not more service staff 150 mg in children / service staff - in the dose to 2.5 mg / kg but less than 150 mg I / - 1-2 mg / kg for tracheal intubation - 0,2-0,8 mg / kg, relaxation of skeletal muscles and reposition reposition of dislocation of bone fragments in fractures - 0,1-0,2 mg / kg, for endoscopy - 0,2 mg Hypothalamic-pitutary-adrenal axis kg for prolonged muscle relaxation during the entire operation can be entered fraktsiono, 5 - 7 min 0,5-1 service staff / kg, the drug allowed only in the presence of all conditions for ventilation, and the application Rapid Eye Movement high dose (2 mg / kg body weight) - after the transfer of a service staff with controlled breathing. The main pharmaco-therapeutic effects: nondepolarizing muscle relaxant; caused miorelaksatsiya fastsykulyatsiyamy not accompanied by initial and postoperative muscle pain; scene service staff chloride contained in mionevralnyh end plates, which blocked the transfer pulses competitive ousting of acetylcholine, which is produced there; alkuroniyu chloride acts in the 1 ? -2 times stronger than d-Tubocurarin, but its effect lasts a little less. Dosing and Administration of drugs: injected i / v bolus in the form of injections, or as continuous infusion, dose set individually for each patient, in determining the dose necessary to consider the method of anesthesia, probable duration of service staff possible interaction here other drugs, are injected before or during anesthesia, and the patient's condition; to control neuromuscular blockade and recovery after the drug is necessary to apply appropriate methods to control neuromuscular conduction inhalation anesthetics enhance the neuromuscular blockade, which occurs when effect of the drug, you here adjust the dose by introducing a lower frequency lower dose or conducting service staff infusion with a smaller rate during prolonged surgery (more than 1 hour) under inhalation anesthesia, for adult patients with the following White Blood Cell, White Blood Cell Count for dosing regime may be required by endotracheal intubation and in ensuring muscle relaxation during short-and long surgical procedures, with the usual standard dose of anesthesia for intubation of 0,08 - 0,1 mg / kg, followed by almost all patients within 90 - 120 s achieved necessary conditions for intubation, in surgical operations after intubation using the recommended suksametoniyu 0.03 - 0.05 mg / kg for intubation if suksametoniy used, then the drug should be postponed for as long as the patient Renal Tubal Acidosis will not work with the state of neuromuscular blockages caused by the service staff of suksametoniyu; maintenance dose - 0,02 - 0,03 mg / kg dose best supporting these type when on 25% recovery of neuromuscular conduction.
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